I usually go to work __________ car.

The correct answer is by. This question assesses your knowledge of prepositions used to describe modes of transport. The preposition "by" is conventionally used to indicate the general method or means of transportation. When you refer to traveling using a specific type of vehicle or method, you typically use "by" followed by the noun without an article. For example, we say "by car," "by bus," "by train," "by plane," "by boat," or "by bicycle." However, if you specify the vehicle with an article or possessive pronoun, you would use a different preposition, such as "in my car" or "on the bus." The other options are incorrect in this context: "on" is used for public transport where you stand or walk (e.g., on the bus, on a train), "with" implies accompaniment or possession, and "from" indicates origin. Therefore, "by car" is the standard and correct idiomatic expression.